The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice.

C Gupta, AS Goldman - Proceedings of the National …, 1986 - National Acad Sciences
arachidonic acid cascade may be involved in the folding and fusion of the … arachidonic acid
cascade leading to prostaglandins may be involved in the mechanism by which testosterone

The role of prostaglandins in masculine differentiation: modulation of prostaglandin levels in the differentiating genital tract of the fetal mouse

C GUPTA - Endocrinology, 1989 - academic.oup.com
… of arachidonic acid prostaglandins (PG) mediates the masculinizing effects of testosterone in
the fetal mouse. … shown that arachidonic acid administered during embryonic development …

Activation of phospholipases during masculine differentiation of embryonic genitalia

C Gupta - Proceedings of the Society for Experimental …, 1988 - journals.sagepub.com
… which testosterone masculinizes the external genitalia involves the arachidonic acid cascade
action of testosterone on embryonic external genitalia in mice. Proc Natl Acad Sci USA 83:…

Role of prostaglandins in the testosterone-dependent wolffian duct differentiation of the fetal mouse

C Gupta, CA Bentlejewski - Biology of reproduction, 1992 - academic.oup.com
… of the external genitalia of the fetal mouse, induced by fetal … dose-dependent manner in
embryonic male explants containing fetal … blocked the anti-masculinizing effects of PG synthesis …

Prostaglandins masculinize the mouse genital tract

C GUPTA - Endocrinology, 1989 - academic.oup.com
… problems associated with the placental transfer of any externalarachidonic acid cascade
is involved in the masculinizing action of testosterone on embryonic external genitalia in mice. …

[HTML][HTML] Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor-indomethacin

A Dean, W Mungall, C McKinnell, RM Sharpe - Plos one, 2013 - journals.plos.org
… androgen effects in the MPW by exposing pregnant rats to … of PGs from arachidonic acid.
PGs are recognized to be … vitro that showed mild inhibition of testosterone production by e14.5 …

[HTML][HTML] Eicosanoid biosynthesis in male reproductive development: effects of perinatal exposure to NSAIDs and analgesic drugs

A Tran-Guzman, M Culty - Frontiers in toxicology, 2022 - frontiersin.org
Mice and rats synthesize testosterone through the Δ 4 … (PGs) from arachidonic acid (AA). The
main steps of the … kg) inhibited the masculinization of male genitalia in GD18 embryos when …

Arachidonic acid and male genital differentiation

AS Goldman - European Journal of Pediatrics, 1987 - Springer
… In this study, the involvement of AA in the male genital … ) The arachidonic acid cascade is
involved in the masculinizing action of testosterone on embryonic external genitalia in mice. …

Lipokinins: Novel Phospholipase A2 Activators Mediatetestosterone Effects on Embryonic Genitalia

AS Goldman, M Katsumata, MP Goto - The Journal of Urology, 1988 - Elsevier
testosterone organizes genital differentiation by androgen receptor-mediated stimulation of
the arachidonic acid cascade at … masculinization of genetic female genitalia in the absence of …

Hypospadias and urethral development

LS Baskin - The Journal of urology, 2000 - Elsevier
Masculinization of the external genitalia occurs under the influence of testosterone in …
Based on analysis of multiple genital tubercles in the mouse we documented urethral seam …